125th anniversary of Science magazine

The 125th anniversary issue of Science magazine includes a special section called "What we don't know" which details 25 of the big questions facing science at the moment and also briefly touches on 100 other questions. Full PDFs are available (at the moment, anyway) from here - just scroll down the page. Now, is it too ambitious for me to want to reach a point in my knowledge of science where I can at least understand all these questions???